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Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU
《医学前沿(英文)》 2010年 第4卷 第3期 页码 317-322 doi: 10.1007/s11684-010-0035-4
关键词: hepatic ischemia-reperfusion digestive tract congestion cholecystokinin vasoactive intestinal peptide salvia miltiorrhiza
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
《医学前沿(英文)》 页码 972-992 doi: 10.1007/s11684-023-0990-1
关键词: inflammatory bowel disease ADT-OH intestinal permeability gut microbiota
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
《化学科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 99-102 doi: 10.1007/s11705-016-1554-6
关键词: cysteine peptide fibrils gold nanoparticles amyloids oligomers nanomaterials
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 368-373 doi: 10.1007/s11684-015-0403-1
Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 μg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P<0.001), whereas GLP-2 pretreatment significantly decreased their levels (P<0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.
关键词: ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase
Altered intestinal microbiota associated with colorectal cancer
Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia
《医学前沿(英文)》 2019年 第13卷 第4期 页码 461-470 doi: 10.1007/s11684-019-0695-7
关键词: colorectal cancer (CRC) gut microbiota intestinal Eubacterium Devosia
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels
LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie
《医学前沿(英文)》 2007年 第1卷 第1期 页码 87-92 doi: 10.1007/s11684-007-0017-3
关键词: significant difference intestinal I/R transcriptase-polymerase metabolic central secretory
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 9-19 doi: 10.1007/s11705-013-1306-9
关键词: insulin cell penetrating peptide mucoadhesive composites oral delivery
Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation
Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,
《工程(英文)》 doi: 10.1016/j.eng.2023.01.015
关键词: Antifreeze peptides Evolution analysis Ice recrystallization inhibition Molecular dynamics simulation Cryopreservation Synthetic biology
电中性固体表面上多条肽链的吸附过程——粗粒化模拟研究 Research
裘若桑, 肖杰, 陈晓东
《工程(英文)》 2020年 第6卷 第2期 页码 185-194 doi: 10.1016/j.eng.2018.12.012
蛋白质在固体表面的吸附过程涉及诸多复杂的分子间相互作用,因此到目前为止仍然无法做到精准调控。通过模拟计算,可以获取固-液界面分子尺度的蛋白质移动机理,从而为预测蛋白质吸附和结垢现象提供可靠的理论依据。本研究通过多尺度粗粒化模型对多条疏水的丙氨酸十二肽在金表面的聚集和吸附过程进行了分析。大约有一半(46.6%)的丙氨酸十二肽可以组成聚集体。30.0%的独立肽链会被快速地吸附到固体表面。这些在表面吸附的肽链经过一段时间的爬行,其中的一些(51.0%)能与吸附在表面的或是游离在溶液中的肽链融合,从而形成吸附在表面的聚集体。这些在固-液界面吸附的肽链使得固体表面性质发生变化。这一变化可能会进一步影响之后溶液中肽链和聚集体在金表面的吸附。本研究揭示的多条肽链吸附机理有希望为进一步研究多个蛋白质分子在固体表面的吸附机理提供理论基础。
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
《化学科学与工程前沿(英文)》 2020年 第14卷 第5期 页码 889-901 doi: 10.1007/s11705-020-1919-8
关键词: gene carriers multitargeting function ECs transfection efficiency
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
《化学科学与工程前沿(英文)》 2021年 第15卷 第1期 页码 220-220 doi: 10.1007/s11705-020-1995-9
Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic
Junjun Jia, Xinyao Tian, Jianwen Jiang, Zhigang Ren, Haifeng Lu, Ning He, Haiyang Xie, Lin Zhou, Shusen Zheng
《医学前沿(英文)》 2019年 第13卷 第4期 页码 451-460 doi: 10.1007/s11684-018-0675-3
关键词: microbial community liver transplantation immunosuppressive agents cyclosporine A
具有泵送控释性能的肠靶向Janus型双腔室海藻酸钙基微胶囊 Article
温霜, 巨晓洁, 刘文英, 刘玉琼, 蒲兴群, 刘壮, 汪伟, 谢锐, Yousef Faraj, 褚良银
《工程(英文)》 2023年 第24卷 第5期 页码 114-125 doi: 10.1016/j.eng.2022.05.021
本文成功开发了一种具有泵送控释特性的θ形双腔室肠靶向海藻酸钙基微胶囊,囊壁为海藻酸钙-壳聚糖/精蛋白/二氧化硅(ACPSi)复合壳,为封装的药物在胃环境中提供了良好保护,实现药物的肠靶向释放。该θ形微胶囊由含药室和助推室两个腔室组成:含药室负载疏水药物吲哚美辛,其囊壁内嵌肠溶性
羟丙甲基纤维素邻苯二甲酸酯(HPMCP)微球,作为“微阀门”(micro-valves);助推室包封助推剂聚丙烯酸(PAA),在肠液环境中,PAA发生溶胀,可提高吲哚美辛释放速率。结果显示,载药的θ-ACPSi 微胶囊在模拟胃液(pH值为2.5)中,吲哚美辛的释放率小于1%。然而,进入模拟肠液(pH值为6.8)时,含药室囊壁中的HPMCP微球溶解,释药“微通道”(microchannel)被打开,同时助推室中的PAA发生溶胀,为药物的释放提供推动力。结果,吲哚美辛在小肠中以恒定的速度释放60%以上。因此,该θ-ACPSi 微胶囊具有良好的泵送和肠靶向控释性能,为口服肠道靶向给药系统的开发提供了一种新策略。
标题 作者 时间 类型 操作
Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract congestion
Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU
期刊论文
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
期刊论文
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Christian Bortolini,Mingdong Dong
期刊论文
Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
null
期刊论文
Altered intestinal microbiota associated with colorectal cancer
Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia
期刊论文
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels
LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie
期刊论文
Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous
Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG
期刊论文
Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation
Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,
期刊论文
Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
期刊论文
Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
期刊论文
Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic
Junjun Jia, Xinyao Tian, Jianwen Jiang, Zhigang Ren, Haifeng Lu, Ning He, Haiyang Xie, Lin Zhou, Shusen Zheng
期刊论文